Research paper

The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

BMC Pregnancy and Childbirth

Mar 2019

DOI: 10.1186/s12884-019-2258-y

Citations: 117

Influential: 10

Interventional (Human) Studies

Study answer

What this study found

Six weeks of magnesium-zinc-calcium-vitamin D co-supplementation improved several inflammation and oxidative stress markers in women with gestational diabetes. In the active arm, hs-CRP decreased from 6.9 ± 1.7 to 5.7 ± 3.7 mg/L (P = 0.01), TAC increased from 619.4 ± 81.1 to 657.6 ± 98.1 mmol/L (P = 0.01), and MDA decreased from 2.9 ± 0.3 to 2.6 ± 0.2 μmol/L (P = 0.003), while total nitrite did not change significantly (43.1 ± 5.5 to 44.3 ± 6.1 μmol/L; P = 0.76) and GSH was not significant (P = 0.32). Nutrient biomarkers also rose, including 25-OH-vitamin D from 12.6 ± 4.2 to 18.7 ± 4.7…

Study & population: Randomized, placebo-controlled, single-center trial in pregnant women with gestational diabetes mellitus who were not using oral hypoglycemic agents.
Intervention: The active intervention was an oral magnesium-zinc-calcium-vitamin D tablet taken twice daily for 6 weeks.
Key limitation: The trial was small, single-center, and short in duration (6 weeks), which limits confidence in clinical outcomes.

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Original abstract

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