Research paper

The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial

Nutrition Journal

Jan 2020

DOI: 10.1186/s12937-020-0524-5

Citations: 57

Influential: 5

Interventional (Human) Studies

Study answer

What this study found

Flaxseed plus lifestyle modification produced better metabolic and anthropometric outcomes than lifestyle modification alone over 12 weeks. Between-group improvements favored flaxseed for insulin concentration, HOMA-IR, triglycerides, HDL cholesterol, hs-CRP, IL-6, adiponectin, leptin, QUICKI, body weight, waist circumference, and BMI, and menstrual regularity also improved. In the flaxseed arm, end-of-study values showed lower weight (73.90 ± 15.20 to 72.99 ± 15.32), waist circumference (88.71 ± 10.99 to 86.88 ± 11.34), BMI (28.38 ± 5.15 to 27.99 ± 5.13), FBS (101.86 ± 12.08 to 94.25 ±…

Study & population: Randomized, open-labeled controlled clinical trial in reproductive-age women with polycystic ovary syndrome diagnosed by Rotterdam criteria.
Intervention: Brown milled flaxseed powder, 30 g/day orally for 12 weeks, supplied in 30 g packets and taken with foods or drinks such as salad, yogurt, or cold beverages.
Key limitation: Single-center study with a small active arm sample and a short 12-week duration, which limits precision and long-term inference.

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Original abstract

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