Research paper

The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease

Lipids in Health and Disease

Jan 2020

DOI: 10.1186/s12944-020-01298-4

Citations: 53

Influential: 4

Interventional (Human) Studies

Study answer

What this study found

Magnesium plus zinc supplementation improved several metabolic, inflammatory, oxidative stress, and mood outcomes versus placebo over 12 weeks. Compared with placebo, fasting plasma glucose fell by 9.44 mg/dL (95% CI -18.30, -0.57; P = 0.03), insulin by 1.37 μIU/mL (95% CI -2.57, -0.18; P = 0.02), HDL-cholesterol increased by 2.09 (95% CI 0.05, 4.13; P = 0.04), CRP decreased by 0.85 (95% CI -1.26, -0.45; P < 0.001), total nitrite increased by 5.13 (95% CI 1.85, 8.41; P = 0.003), and total antioxidant capacity increased by 43.44 (95% CI 3.39, 83.50; P = 0.03). Beck Depression Inventory and…

Study & population: Randomized, placebo-controlled, 12-week trial conducted at a cardiology clinic affiliated with Kashan University of Medical Sciences in Kashan, Iran.
Intervention: Magnesium plus zinc co-supplementation consisted of magnesium oxide 250 mg/day plus zinc sulfate 150 mg/day, providing 30 mg elemental zinc, taken daily for 12 weeks.
Key limitation: The trial was small, single-center, and short in duration, which limits certainty about long-term efficacy and safety.

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