Research paper
The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial
Citations: 36
Influential: 3
Interventional (Human) Studies
87
Study answer
What this study found
Vitamin D plus magnesium co-supplementation improved behavioral and mental health outcomes versus placebo over 8 weeks. SDQ scores favored the intervention group for emotional problems (p = 0.001), conduct problems (p = 0.002), peer problems (p = 0.001), prosocial score (p = 0.007), total difficulties (p = 0.001), externalizing (p = 0.001), and internalizing (p = 0.001). Reported effect sizes were moderate to large, including total difficulties (Cohen's d = -0.712) and internalizing (-0.855). Serum 25-OH-vitamin D and magnesium also increased significantly in the intervention group, and no…
- Study & population
- Randomized controlled trial in children with ADHD recruited from clinical settings in Isfahan, Iran.
- Intervention
- Children in the active arm received oral vitamin D 50,000 IU/week (pearl) with lunch plus oral magnesium 6 mg/kg/day (tablet) with lunch for 8 weeks, compared with placebo.
- Key limitation
- The intervention period was short at 8 weeks, and outcomes were limited mainly to SDQ scores and serum biomarkers.
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