Research paper

The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial

BioMed Research International

Oct 2021

DOI: 10.1155/2021/5588275

Citations: 13

Influential: 1

Interventional (Human) Studies

Study answer

What this study found

No significant differences were observed in semen parameters or pregnancy rates between the vitamin E and placebo groups. However, a significant decrease in normal sperm percentage was noted in the placebo group after treatment.

Study & population: 124 infertile couples with male factor infertility were randomly assigned to receive either vitamin E or a placebo.
Intervention: Oral synthetic vitamin E (400 IU/day) was administered for eight weeks to infertile men with abnormal semen parameters.
Key limitation: Only a low dose of vitamin E was administered for a short duration, which may have limited the ability to observe significant effects.

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Original abstract

Background Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are p…