Research paper

The Effect of Microbiome-modulating Probiotics, Prebiotics and Synbiotics on Glucose Homeostasis in Type 2 Diabetes: A Systematic Review, Meta-Analysis, and Meta-Regression of Clinical Trials.

Pharmacological research

Oct 2022

DOI: 10.1016/j.phrs.2022.106520

Citations: 35

Influential: 1

Systematic Reviews / Meta-Analyses

Study answer

What this study found

Overall, pro/pre/synbiotic supplementation improved glucose homeostasis in adults with type 2 diabetes. The meta-analysis found significant reductions in fasting plasma glucose, HbA1c, fasting insulin, and HOMA-IR, along with improved QUICKI, while C-peptide did not change significantly. Effects varied by age, baseline BMI, baseline biomarker values, dose, duration, nutraceutical type, and recruitment region. Synbiotics, particularly multispecies formulations, showed notable HbA1c benefits and support these nutraceuticals as potential adjuncts to pharmacological therapy.

Study & population: This was a systematic review, meta-analysis, and meta-regression of clinical trials in adults with type 2 diabetes from diverse geographic regions.
Intervention: The review evaluated microbiome-modulating nutraceuticals as adjuncts to usual diabetes care, including probiotics, prebiotics, and synbiotics.
Key limitation: The evidence base was highly heterogeneous in formulation, dose, duration, participant characteristics, and region, which limits comparability and precision.

View source

Open PDF

Original abstract

No abstract is available for this paper.