The effect of lycopene supplement from different sources on prostate specific antigen (PSA): A systematic review and meta-analysis of randomized controlled trials.

Study answer

What this study found

Lycopene supplementation did not significantly reduce PSA compared with control, and the null effect was consistent across subgroups. Across the included trials, PSA responses were mixed, with some studies reporting reductions, others increases, and one reporting no difference in PSA change. The meta-analysis included 6 studies and 298 participants, but the authors concluded that the overall evidence does not support a meaningful PSA-lowering effect. They recommended larger, more consistent randomized trials to clarify whether any true benefit exists.

Study & population

Systematic review and meta-analysis of randomized controlled trials in men.

Intervention

Randomized trials evaluated lycopene delivered as tomato-derived products or purified/synthetic lycopene, compared with control/placebo.

Key limitation

The evidence base was small, with only 6 studies contributing to the meta-analysis and substantial heterogeneity across sources, doses, durations, and patient populations.

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Original abstract