The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized Placebo-Controlled Trial

Study answer

What this study found

Caloric restriction resulted in a significant increase in the bone resorption marker CTX-I, indicating potential adverse effects on bone health. Supplementation with n-3 PUFAs did not positively affect bone turnover markers, suggesting that the negative impacts of caloric restriction on bone may not be mitigated by n-3 PUFAs.

Study & population

Participants included 64 middle-aged adults (BMI 25–40 kg/m2) with abdominal obesity.

Intervention

This trial investigated the effects of caloric restriction and n-3 PUFA supplementation on bone turnover markers in middle-aged individuals with abdominal obesity over a 3-month period.

Key limitation

The study did not assess physical activity levels or measure other hormones that influence bone metabolism.

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Original abstract