Research paper
The American Cancer Society Cancer Prevention Study II Nutrition Cohort
Study answer
What this study found
A large, long-term prospective resource created to study cancer risk and survival in relation to obesity/weight change, physical activity at various life stages, vitamin supplement use, exogenous hormone use, and medications, plus cancer screening modalities. It includes over 160,000 cancer-free adults (77,048 men; 85,360 women) from 21 states, with detailed dietary and lifestyle data, repeated exposure assessments, and biological samples (blood from 39,200; buccal DNA from 50,000). This design enables robust internal analyses and nested case–control studies of cancer outcomes, and its…
- Study & population
- Prospective cohort (Cancer Prevention Study II Nutrition Cohort) established in 1992–1993 as a subgroup of the CPS-II; baseline questionnaire mailed to 516,671 CPS-II men and women aged 50–74 across 21 states; ~90% follow-up; completed questionnaires from 55,105 CPS-II men and 50,937 CPS-II women; a second mail-out expanded to 86,406 men and 97,788 women;…
- Key limitation
- Not a random, population-based sample; selected cohort designed to optimize data quality and follow-up, which may limit generalizability to the broader population.
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Open PDFOriginal abstract
Large‐scale, prospective cohort studies have played a critical role in discovering factors that contribute to variability in cancer risk in human populations. Epidemiologists and volunteers at the American Cancer Society (ACS) were among the first to…