Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men.

Study answer

What this study found

KS oil was associated with worse insulin sensitivity and a more adverse metabolic profile than control oil. The primary Matsuda index was lower with KS oil than with control oil (4.57 vs 5.33; P = 0.049), and the difference remained after adjustment for omega-3 index (4.04 vs 5.53; P = 0.009). Within-group KS-oil changes also showed an 18% decrease in Matsuda index (P = 0.002), a 0.39 increase in HOMA-IR (P = 0.016), and a 1.39 mU/L increase in fasting insulin (P = 0.048). Most secondary outcomes were not significantly different, although apolipoprotein B was higher with KS oil (P = 0.053)…

Study & population

Randomized, double-blind, controlled crossover trial in overweight, otherwise healthy middle-aged men in Auckland, New Zealand.

Intervention

Participants took 5 oral 1000-mg capsules daily of KS oil for 8 weeks in a randomized crossover design, with an 8-week washout between periods.

Key limitation

The trial was small, short term, and limited to overweight men, which reduces generalizability.

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Original abstract