Research paper
Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome
Study answer
What this study found
Selenium supplementation was associated with better reproductive and selected inflammatory/oxidative stress outcomes in women with PCOS. In the selenium group, pregnancy rate was 18.8% (6/32) versus 3.1% (1/32) in placebo, p = 0.04; alopecia was 40.6% versus 9.4%, p = 0.004; and acne was 46.9% versus 12.5%, p = 0.003. DHEA decreased from 2.01 ± 0.80 to 1.65 ± 0.85, p = 0.02; hs-CRP decreased from 2 184.06 ± 2 693.84 to 1 472.70 ± 1 444.43, p = 0.02; and MDA decreased from 4.95 ± 1.25 to 4.81 ± 1.36, p = 0.01. No significant changes were seen for NO, TAC, GSH, or several other…
- Study & population
- Placebo-controlled interventional study in women aged 18-40 years with polycystic ovary syndrome meeting Rotterdam criteria and undergoing infertility assessment/treatment in Ardabil, Iran.
- Intervention
- The active intervention was oral selenium yeast, 200 μg daily as a tablet for 8 weeks.
- Key limitation
- The intervention period was short at 8 weeks and the active arm sample size was small (32 participants).
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Open PDFOriginal abstract
Abstract Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplemen…