Research paper
Selenium, Selenoenzymes, Oxidative Stress and Risk of Neoplastic Progression from Barrett's Esophagus: Results from Biomarkers and Genetic Variants
Study answer
What this study found
Serum selenium concentration showed no association with risk of EA, aneuploidy, or tetraploidy (HR per 50 mg/L increase: EA 1.16 [0.60–2.28], aneuploidy 1.64 [0.79–3.42], tetraploidy 1.06 [0.54–2.06]; P for trend 0.25–0.85). SEPP1 concentration was positively associated with risk: per 1 mg/L increase, EA HR 1.46 (1.05–2.05); highest SEPP1 tertile vs lowest HR 3.95 (1.42–10.97) for EA and 6.53 (1.31–32.58) for aneuploidy (P for trend = 0.006 and 0.02). GPX1/GPX3 activities and oxidative stress markers (MDA, PCC) were not associated with progression. Two GPX3 SNPs showed nominal associations…
- Study & population
- Design: Prospective cohort study of Barrett’s esophagus (BE) patients.
- Key limitation
- Small number of endpoints with limited statistical power; cohort largely selenium-replete with few participants below proposed protective thresholds; single baseline selenium measurement may not reflect long-term exposure or tissue selenium; generalizability limited to BE patients; some SNP analyses limited by sample…
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Open PDFOriginal abstract
Clinical trials have suggested a protective effect of selenium supplementation on the risk of esophageal cancer, which may be mediated through the antioxidant activity of selenoenzymes. We investigated whether serum selenium concentrations, selenoenz…