Rutosides for treatment of post-thrombotic syndrome.

Study answer

What this study found

There was no evidence that rutosides improved post-thrombotic syndrome more than placebo or elastic compression stockings. Across the three studies (233 participants), the main findings were largely null: in one trial, improvement in tiredness was 46% with rutosides versus 26% with placebo, but oedema/swelling reduction was 20/41 versus 18/42 and pain reduction was 16/41 versus 14/42; in another, improvement was 26/40 with rutosides versus 28/40 with elastic compression stockings. The review concluded that the available evidence is limited and of low or very low quality, providing no…

Study & population

Systematic review of 3 randomized trials in adults with post-thrombotic syndrome after venography-proven deep venous thrombosis.

Intervention

Rutosides were given orally as 0-(β-hydroxyethyl)-rutosides in doses of 900 mg/day for 6 months, 1200 mg/day for 8 weeks, or 2000 mg/day in two divided doses for 12 months.

Key limitation

Evidence came from only 3 small trials with 233 total participants and substantial variation in dose, duration, and comparator.

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Original abstract