Research paper
Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
Citations: 146
Influential: 2
Interventional (Human) Studies
93
Study answer
What this study found
Resistant starch produced clinically meaningful weight loss and improved metabolic markers versus corn starch. Body weight decreased by a net -2.81 kg (95% CI -3.55 to -2.07; P < 0.001), with reductions in fat mass, waist circumference, visceral fat area, and subcutaneous fat area. Insulin sensitivity improved, with glucose infusion rate increasing significantly after resistant starch (P = 0.025; median increase 1.05 mg kg -1 min -1, 0.15 to 2.10), and inflammatory markers TNFα and IL-1β decreased. Adiponectin increased and FGF21 decreased, with no reported adverse gastrointestinal effects.…
- Study & population
- Randomized crossover trial in adults with overweight or obesity (BMI ≥ 24 kg/m2) in Shanghai, China.
- Intervention
- Adults in the resistant starch arm received 40 g/day of type 2 resistant starch (HAM-RS2; maize resistant starch) for 8 weeks by mouth.
- Key limitation
- The trial was small, single-center, and short term, so durability of weight loss and metabolic effects is unknown.
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