Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study

Study answer

What this study found

Higher dietary histidine intake is associated with lower BMI, waist circumference, and blood pressure; higher histidine intake links to lower prevalence of overweight/obesity and abdominal obesity. Multivariable-adjusted ORs for overweight/obesity: 0.745 (0.572–0.969) for the 3rd quartile and 0.650 (0.482–0.876) for the 4th quartile vs 1st quartile. For abdominal obesity, ORs were 0.716 (0.539–0.952) for Q2, 0.809 (0.597–0.995) for Q3, and 0.754 (0.545–0.943) for Q4, with stronger significance in women. In overweight/obese participants, higher histidine is associated with lower fasting…

Study & population

Internet-based cross-sectional study in northern Chinese adults evaluating associations between dietary histidine and obesity.

Key limitation

Cross-sectional design limits causal inference; potential reverse causality; population limited to northern Chinese adults; lack of data on histidine-containing peptides; possible residual confounding; dietaryAssessment reliance on self-report (IDQC).

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Original abstract