Research paper
Rationale and design of the IRON-AF study: a double-blind, randomised, placebo-controlled study to assess the effect of intravenous ferric carboxymaltose in patients with atrial fibrillation and iron deficiency
Citations: 12
Influential: 1
Interventional (Human) Studies
90
Study answer
What this study found
The trial aims to provide clinically relevant evidence regarding the effect of iron repletion on exercise tolerance, fatigue, quality of life, and AF disease burden.
- Study & population
- At least 84 patients with paroxysmal or persistent atrial fibrillation and iron deficiency will be recruited.
- Intervention
- A double-blind, randomised, placebo-controlled trial designed to assess the effect of intravenous ferric carboxymaltose in patients with atrial fibrillation and iron deficiency.
- Key limitation
- Self-reported questionnaires may limit the demonstration of improvement in symptoms.
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Open PDFOriginal abstract
Introduction Atrial fibrillation (AF) is associated with significantly impaired quality-of-life. Iron deficiency (ID) is prevalent in patients with AF. Correction of ID in other patient populations with intravenous iron supplementation has been shown…