Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children.

Study answer

What this study found

Vitamin D3 improved winter-related atopic dermatitis compared with placebo, and no major or minor adverse events were reported. At 1 month, the average percent change in baseline EASI was 29% with vitamin D3 versus 16% with placebo (P = .02), and IGA also favored vitamin D3 (Fisher exact test P = .03; P for trend = .04). Parental assessment that the dermatitis was better than baseline was also significant at 1 month, 64% versus 43% (P = .03), but not at 2 weeks, 45% versus 33% (P = .24).

Study & population

Randomized placebo-controlled trial in Mongolian children with winter-related atopic dermatitis recruited from outpatient clinics in Ulaanbaatar during February to March 2009.

Intervention

Vitamin D3 was given as oral cholecalciferol, one drop providing 1000 IU daily for 1 month, compared with placebo.

Key limitation

The trial was short, with only 1 month of follow-up, so durability of benefit is unknown.

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Original abstract