Research paper

Prospective Study of Vitamin D Status at Initiation of Care in Critically Ill Surgical Patients and Risk of 90-Day Mortality*

Critical Care Medicine

Jun 2014

DOI: 10.1097/CCM.0000000000000210

Citations: 109

Influential: 5

Observational Studies (Human)

Study answer

What this study found

Vitamin D status at ICU initiation predicted all three outcomes (hospital length of stay, 90-day readmission, and 90-day mortality). All four measures (total 25(OH)D, bioavailable 25(OH)D, total 1,25(OH)2D, and bioavailable 1,25(OH)2D) were predictive; total 25(OH)D was not inferior to the others. Within 24 hours of ICU admission, higher total 25(OH)D was associated with shorter hospital LOS (IRR per 1 ng/mL 0.98, 95% CI 0.97–0.98) and lower risk of 90-day readmission (OR per 1 ng/mL 0.84, 95% CI 0.74–0.95) and 90-day mortality (OR per 1 ng/mL 0.83, 95% CI 0.73–0.97). The 90-day readmission…

Study & population: Design: Prospective cohort study conducted in two 18-bed surgical ICUs at Massachusetts General Hospital, Boston.
Key limitation: Small, single-center observational study (n=100); potential residual confounding; bioavailable D estimated from formula-based methods; limited power to assess ICU LOS; findings may not generalize to medical ICU or non-surgical populations; possible missing readmission data if admitted elsewhere; cannot establish…

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Original abstract

Objectives:1) To characterize vitamin D status at initiation of critical care in surgical ICU patients and 2) to determine whether this vitamin D status is associated with the risk of prolonged hospital length of stay, 90-day readmission, and 90-day …