Research paper
Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of Randomized Controlled Trials
Study answer
What this study found
The supplement strategies showed benefits, with different products ranking best for different outcomes. Prebiotics were superior for IL-6 (SMD -0.74; 95% CI [-1.32, -0.16]), TNF-α (SMD -0.59; 95% CI [-1.09, -0.08]), indoxyl sulfate (SMD -0.43; 95% CI [-0.81, -0.05]), blood urea nitrogen (SMD -0.42; 95% CI [-0.78, -0.06]), and malondialdehyde (SMD -1.88; 95% CI [-3.02, -0.75]). Synbiotics were best for C-reactive protein (SMD -0.69; 95% CI [-1.14, -0.24]) and endotoxin (SMD -0.83; 95% CI [-1.38, -0.27]), while probiotics were most effective for gastrointestinal symptoms (GSRS; SMD -0.52; 95%…
- Study & population
- Network meta-analysis of 25 randomized controlled trials including 1,106 adults with end-stage renal disease undergoing dialysis.
- Intervention
- Probiotics, prebiotics, and synbiotics were compared with placebo in randomized trials of adults with end-stage renal disease undergoing dialysis.
- Key limitation
- The evidence base included only a small number of multi-arm trials, and the included studies were heterogeneous.
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Open PDFOriginal abstract
Background Probiotics, prebiotics, and synbiotics are three different supplements to treat end stage renal disease (ESRD) patients by targeting gut bacteria. The comprehensive comparison of the effectiveness of different supplements are lacking. Obje…