Research paper
Probiotics for prevention of atopic diseases in infants: systematic review and meta‐analysis
Study answer
What this study found
Probiotics reduced infantile eczema overall, but they did not prevent asthma, wheezing, or rhinoconjunctivitis. For eczema, the pooled risk ratio was 0.78 (95% CI 0.69-0.89; P = 0.0003), and probiotic mixtures showed a stronger effect (RR 0.54, 95% CI 0.43-0.68; P < 0.00001) than single-strain Lactobacilli (RR 0.90, 95% CI 0.77-1.05; P = 0.18) or Bifidobacteria (RR 0.89, 95% CI 0.73-1.08; P = 0.23). The pooled estimates for asthma (RR 0.99, 95% CI 0.77-1.27), wheeze (RR 1.02, 95% CI 0.89-1.17), and rhinoconjunctivitis (RR 0.91, 95% CI 0.67-1.23) were not significant. Probiotics were…
- Study & population
- Systematic review and meta-analysis of 17 studies including 4755 children, with 2381 in probiotic groups and 2374 in control groups.
- Intervention
- Across included trials, the active intervention was oral probiotic supplementation given to mothers during pregnancy and/or to infants in early life, with regimens ranging from gestational week 24 to 36, 2 months before delivery, or after birth, and continuing from 6 months to 2 years depending on the study.
- Key limitation
- The evidence was heterogeneous because trials used different probiotic strains, mixtures, start times, and treatment durations.
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Open PDFOriginal abstract
Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic supplementation in childhood might prevent atopic diseases. The aim of the p…