Research paper

Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects.

Kidney international

Feb 2017

DOI: 10.1016/j.kint.2016.09.040

Citations: 179

Influential: 8

Interventional (Human) Studies

Study answer

What this study found

Twelve weeks of probiotic supplementation was associated with better glycemic control and favorable changes in some inflammatory and oxidative stress markers, while lipid profiles were not markedly affected. In the probiotic group, fasting plasma glucose fell from 126.3 to 104.3 (change −22.0), insulin from 21.6 to 15.2 (change −6.4), HOMA-IR from 6.9 to 4.0 (change −2.9), QUICKI rose from 0.29 to 0.32 (change 0.03), and HbA1c fell from 5.9 to 5.5 (change −0.4). hs-CRP declined from 8043.3 to 6110.0 (change −1933.3) and MDA from 2.4 to 2.1 (change −0.3), whereas triglycerides, total…

Study & population: This 12-week interventional study enrolled adults with diabetes receiving regular hemodialysis at Akhavan Clinic in Kashan, Iran.
Intervention: Participants in the probiotic arm took one oral capsule daily for 12 weeks containing Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium bifidum (2 × 10^9 CFU/g each).
Key limitation: Interpretation is limited by the modest sample size in the probiotic arm (n=30), the short 12-week follow-up, and the single-center setting in Kashan, Iran.

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