Research paper

Premenopausal plasma carotenoids, fluorescent oxidation products, and subsequent breast cancer risk in the nurses’ health studies

Breast Cancer Research and Treatment

Apr 2015

DOI: 10.1007/s10549-015-3391-6

Citations: 25

Influential: 3

Observational Studies (Human)

Study answer

What this study found

Carotenoids measured in premenopausal plasma were not inversely associated with overall breast cancer risk (total carotenoids top vs bottom quartile RR 0.99, 95% CI 0.77–1.28; p-trend = 0.67). No differences by estrogen receptor status. Lycopene showed a potential inverse association with postmenopausal breast cancer (top vs bottom quartile RR 0.66, 95% CI 0.45–0.96; p-trend = 0.02). FlOP biomarkers were not positively associated with risk; FlOP_360 top vs bottom RR 0.68 (95% CI 0.50–0.95; p-trend = 0.07); FlOP_320 RR 0.76 (95% CI 0.55–1.06; p-trend = 0.08). Significant interactions by…

Study & population: Two prospective cohorts (Nurses' Health Study and Nurses' Health Study II) with a nested case-control design; female nurses; premenopausal at blood collection for carotenoid analyses; 1,179 case-control pairs; cases diagnosed with breast cancer; controls matched on age, time of blood draw, fasting status, and menopausal status; plasma carotenoids measured…
Key limitation: Biomarkers measured at a single time point; potential measurement error and batch variability (recalibrated)); multiple statistical tests without formal adjustment; residual confounding possible due to observational design; limited generalizability beyond premenopausal, female nurses and specific exposure window.

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