Research paper
Perioperative nutrition for the treatment of bladder cancer by radical cystectomy.
Study answer
What this study found
Overall, evidence for perioperative nutrition after radical cystectomy was limited and of low to very low certainty. Some regimens may help: immuno-enhancing nutrition may reduce 90-day complications, preoperative oral nutrition and amino acids with dextrose versus dextrose alone may reduce 30-day complications, and perioperative oral nutritional supplements may slightly decrease complications with little effect on length of stay. By contrast, parenteral nutrition compared with oral nutrition may increase complications (RR 1.40, 1.07 to 1.82), and early postoperative feeding showed little to…
- Study & population
- Systematic review and meta-analysis of randomized trials in adults undergoing radical cystectomy for bladder cancer.
- Intervention
- Perioperative nutrition strategies varied across trials and included parenteral nutrition with dextrose and amino acids, branched-chain amino acid-containing IV solutions, preoperative oral nutritional supplements, immunonutrition drinks containing arginine and omega-3 fatty acids, and early postoperative feeding.
- Key limitation
- The evidence base was small, heterogeneous, and largely composed of older trials with methodological limitations.
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Open PDFOriginal abstract
BACKGROUND Radical cystectomy (RC) is the primary surgical treatment for muscle-invasive urothelial carcinoma of the bladder. This major operation is typically associated with an extended hospital stay, a prolonged recovery period and potentially maj…