Research paper
Perioperative immunonutrition in patients undergoing liver transplantation: A randomized double‐blind trial
Citations: 69
Influential: 4
Interventional (Human) Studies
87
Study answer
What this study found
Perioperative immunonutrition did not improve preoperative nutritional status or postoperative outcomes after liver transplantation. Total body protein changed by 0.06 6 0.15 kg in the immunonutrition group versus 0.12 6 0.10 kg in control, with no significant between-group difference (P = 0.74). Total body fat, grip strength, respiratory muscle strength, and fatigue also showed no meaningful benefit. Preoperative adverse events were similar, and graft-related outcomes were comparable, with rejection in 19 versus 21 and steroid-resistant rejection in 1 versus 1.
- Study & population
- Randomized, double-blind trial in adults with end-stage liver disease who were wait-listed for orthotopic liver transplantation at Auckland City Hospital, New Zealand.
- Intervention
- Perioperative immunonutrition was given as Oral Impact powder, 2 sachets per day (74 g each) orally before transplant; when reconstituted, this provided 600 mL/day at 1 kcal/mL containing 7.5 g arginine, 2 g n-3 fatty acids, and 0.8 g ribonucleic acid.
- Key limitation
- The active-arm sample was modest, and supplementation exposure varied widely, with days on supplement ranging from 0 to 480 in the immunonutrition group.
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