Periconceptional multiple-micronutrient supplementation and placental function in rural Gambian women: a double-blind, randomized, placebo-controlled trial

Study answer

What this study found

Periconceptional UNIMMAP produced a modest improvement in uterine-artery vascular indices, but most placental function measures and birth outcomes were unchanged, so the clinical importance remains uncertain. At 18-22 weeks, uterine artery PI was lower with UNIMMAP than placebo (1.12 vs 1.20; difference -0.08, 95% CI -0.16 to -0.01; P = 0.025) and uterine artery RI was also slightly lower (0.61 vs 0.63; P = 0.050). Longitudinally, UNIMMAP reduced UtARI by 0.02 units over 18-32 weeks (95% CI -0.03 to -0.00; P = 0.040), but there was no effect on PAI-1, PAI-2, PAI-1:PAI-2 ratio, hCG, hPL, or…

Study & population

Double-blind, randomized, placebo-controlled trial in rural Gambian women of reproductive age who were menstruating and not pregnant at enrollment.

Intervention

The active intervention was UNIMMAP, a coated multiple-micronutrient tablet containing 15 vitamins and trace elements.

Key limitation

The key biological effects were small, and several analyses used reduced sample sizes, which limits precision.

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Original abstract