Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Study answer

What this study found

A single dose of orange juice increased circulating flavanone and phenolic metabolites, but neither orange juice nor hesperidin improved cardiovascular risk biomarkers over 5 hours. Total plasma flavanone metabolites were higher after orange juice than control (1.75 ± 0.35 mmol/L), and total phenolics were also higher (13.27 ± 2.22 mmol/L). Hesperidin metabolites after the hesperidin supplement did not differ from control (P = 0.9), and plasma vitamin C increased similarly after all interventions. No significant differences were seen for endothelial function, blood pressure, arterial…

Study & population

Randomized, placebo-controlled, crossover trial conducted in the United Kingdom in healthy nonsmoking men at moderate cardiovascular disease risk.

Intervention

Participants received a single oral dose of either 767 mL orange juice providing 320 mg hesperidin or a dose-matched 320 mg hesperidin supplement; both interventions were matched for vitamin C and sugars and were compared with control in a crossover design.

Key limitation

The trial was small, with only 14 completers per active intervention period, and it assessed only acute effects after a single dose.

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Original abstract