Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes
What this study found
Bovine colostrum improved intestinal permeability and lowered stool zonulin compared with placebo, with the overall effect judged beneficial. Colostrum supplementation significantly decreased intestinal permeability (p = 0.01), and the post-intervention change in zonulin differed from placebo (p = 0.03). In the open-label crossover phase, differential sugar absorption also differed (p = 0.02), with zonulin changes remaining significant at day 44 versus day 22 (p = 0.0008) and day 44 versus day 0 (p = 0.006). The intervention was generally well tolerated, with no important…
- Study & population
- Randomized placebo-controlled interventional trial in healthy male professional mixed martial arts fighters undergoing intensive in-season training.
- Intervention
- The active regimen was oral freeze-dried whole bovine colostrum powder, 500 mg per dose twice daily for 20 days.
- Key limitation
- Very small active-arm sample size and short 20-day intervention limit precision and generalizability.
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Open PDFOriginal abstract
Increased intestinal permeability has been implicated in various pathologies, has various causes, and can develop during vigorous athletic training. Colostrum bovinum is a natural supplement with a wide range of supposed positive health effects, including reduction of intestine permeability. We assessed influence of colostrum supplementation on intestinal permeability related parameters in a group of 16 athletes during peak training for competition. This double-blind placebo-controlled study compared supplementation for 20 days with 500 mg of colostrum bovinum or placebo (whey). Gut permeability status was assayed by differential absorption of lactulose and mannitol (L/M test) and stool zonulin concentration. Baseline L/M tests found that six of the participants (75%) in the colostrum group had increased intestinal permeability. After supplementation, the test values were within the normal range and were significantly lower than at baseline. The colostrum group Δ values produced by comparing the post-intervention and baseline results were also significantly lower than the placebo group Δ values. The differences in stool zonulin concentration were smaller than those in the L/M test, but were significant when the Δ values due to intervention were compared between the colostrum group and the placebo group. Colostrum bovinum supplementation was safe and effective in decreasing of intestinal permeability in this series of athletes at increased risk of its elevation.