Research paper

Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial.

The American journal of clinical nutrition

Jul 2012

DOI: 10.3945/ajcn.112.034207

Citations: 23

Influential: 1

Interventional (Human) Studies

Study answer

What this study found

Oral magnesium supplementation improved respiratory muscle strength and clinical status in pediatric cystic fibrosis, with no adverse effects reported. In the magnesium arm, urinary magnesium increased from 39.69 6 9.46 to 76.08 6 16.09 mg/d, SK score improved from 80.05 6 10.65 to 84.52 6 9.62, and both MIP and MEP increased by about 11% to 12% predicted. The improvements in MIP, MEP, and SK score were all significant (P < 0.001).

Study & population: Double-blind, randomized, placebo-controlled crossover trial conducted at a single center in Brazil.
Intervention: Oral magnesium-glycine (magnesium amino acid chelate) was given at 300 mg/day once daily for 8 weeks, with a 4-week washout between crossover periods.
Key limitation: The trial was small, single-center, and limited to pediatric cystic fibrosis patients, which restricts generalizability.

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Original abstract

BACKGROUND Magnesium is one of the most important minerals in the body. Although some studies reported that patients with cystic fibrosis (CF) lack magnesium, no international study has assessed the importance of oral magnesium supplementation in CF …