Research paper
Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial
Study answer
What this study found
Perioperative curcumin did not improve the biomarker panel, hospital stay, or overall clinical outcomes. Postoperative urine IL-18 was 13 (6 to 27) with curcumin versus 16 (7 to 30) with placebo (p = 0.2), serum creatinine rise was 1 (-7 to 19) versus 1 (-6 to 12) (p = 0.2), NT-pro-BNP was 221 (67 to 511) versus 184 (48 to 431) (p = 0.1), and hs-CRP was 58 (28 to 95) versus 58 (30 to 90) (p = 0.9). Acute kidney injury was higher with curcumin, 51 (17) versus 30 (10) with placebo (p = 0.01), while hospital length of stay was 5 (2 to 8) versus 5 (2 to 7) (p > 0.9) and the composite of clinical…
- Study & population
- Multicenter randomized controlled trial in adults undergoing elective abdominal aortic aneurysm repair, either open or endovascular, at 10 academic hospitals in 4 provinces.
- Intervention
- Oral curcumin capsules containing 95% curcumin from Curcuma longa were given perioperatively.
- Key limitation
- The intervention was short-term and perioperative, so it may not address longer-term outcomes.
View source
Open PDFOriginal abstract
BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral cur…