Research paper
Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire
Study answer
What this study found
Psoriatic men consumed more total and simple carbohydrates, total fat, PUFA and cholesterol, and less protein, complex carbohydrates, MUFA, n-3 PUFA and fiber than controls, with no difference in total energy or SFA. They had worse metabolic profiles (CRP, HoMA-IR), higher VAI and FLI, and greater prevalence of hepatic steatosis. PASI score correlated with anthropometric measures, glucose and lipid profiles, liver function tests, cardio-metabolic indices, and most dietary components (except protein and total carbohydrates). In multivariable analyses, MUFA intake was the strongest dietary…
- Study & population
- Design: cross-sectional case-control observational study.
- Key limitation
- Male-only sample (selection bias) and small sample size; cross-sectional design limits causal inference; use of surrogate markers (VAI, FLI) with partial validation (FLI reliability not fully established); results may not generalize to women or other populations.
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Open PDFOriginal abstract
BackgroundWestern dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association between diet and psoriasis. The 7…