No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial

Study answer

What this study found

Resveratrol did not improve insulin sensitivity after 6 months. The primary outcome, Matsuda index, was not different from placebo postintervention (5.18 ± 0.35 vs 5.50 ± 0.34; P = 0.549). HbA1c was lower with resveratrol (35.8 ± 0.43 mmol/mol vs 37.6 ± 0.44; P = 0.007), but intrahepatic lipid content was not significantly changed (F(1, 34) = 2.510, P = 0.122) and other glucose/insulin measures were comparable between arms. No adverse events were reported.

Study & population

Randomized, double-blind, placebo-controlled trial in overweight to obese adults, including middle-aged and older men and postmenopausal women.

Intervention

Oral trans-resveratrol (resVida, 99.9%) at 150 mg/day, given as two 75 mg supplements daily with lunch and dinner for 6 months.

Key limitation

Small active group size (n = 20) limits precision and generalizability.

View full study detailsView sourceOpen PDF

Original abstract