Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial.

Study answer

What this study found

The MFGM-supplemented formula improved cognitive performance at 12 months compared with standard formula and brought scores close to those seen in breastfed infants. On Bayley-III, the EF group scored 105.8 6 9.2 versus 101.8 6 8.0 in the SF group, a 4.0-point higher score (95% CI: 1.1, 7.0; P = 0.008); the breastfed reference group scored 106.4 6 9.5, which was not different from EF (P = 0.73). There were no significant differences in linear growth, weight gain, BMI, percentage body fat, or head circumference between the two formula groups. Infants in the EF group consumed more formula (864…

Study & population

Randomized controlled trial in Sweden among healthy term infants 37 to 42 weeks' gestation, birth weight 2500 to 4500 g, and age 2 months or younger at inclusion.

Intervention

Infants in the experimental arm received a powdered low-energy, low-protein formula supplemented with bovine milk fat globule membrane (MFGM) fraction Lacprodan MFGM-10, fed orally from enrollment before 2 months of age until 6 months of age.

Key limitation

The trial was relatively small and conducted in a single Swedish center, which limits generalizability.

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Original abstract