Multimodal nutritional rehabilitation improves clinical outcomes of malnourished patients with chronic respiratory failure: a randomised controlled trial

Study answer

What this study found

The multimodal program improved body composition, muscle function, exercise capacity, and some patient-reported outcomes, but did not significantly improve the primary 6-minute walk distance outcome. Compared with control, BMI increased by 0.56 kg/m2 (95% CI 0.18 to 0.95, p=0.004), FFMI by 0.60 kg/m2 (95% CI 0.15 to 1.05, p=0.01), haemoglobin by 9.1 g/l (95% CI 2.5 to 15.7, p=0.008), peak workload by 7.2 W (95% CI 3.7 to 10.6, p<0.001), quadriceps isometric force by 28.3 N (95% CI 7.2 to 49.3, p=0.009), and endurance time by 5.9 min (95% CI 3.1 to 8.8, p<0.001). In women, CRQ improved by…

Study & population

Multicentre randomized controlled trial conducted across eight respiratory units.

Intervention

The active regimen was a 3-month home-based multimodal rehabilitation program that included oral nutritional supplements and oral testosterone undecanoate, alongside exercise training and health education.

Key limitation

The intervention was a bundled multimodal program, so the specific contribution of the oral nutritional supplement cannot be isolated.

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Original abstract