Micronutrient supplementation interventions in preconception and pregnant women at increased risk of developing pre-eclampsia: a systematic review and meta-analysis

Study answer

What this study found

Calcium and vitamin D supplementation were associated with a lower rate of preeclampsia in high-risk women, while other micronutrient regimens did not show consistent benefit. Pooled effects were risk difference -0.15 for calcium (95% CI -0.27, -0.03; I2 = 83.41%) and -0.09 for vitamin D (95% CI -0.17, -0.02; I2 = 0.00%). Vitamin C plus vitamin E showed only a small, non-significant trend overall (risk difference -0.04, 95% CI -0.09, 0.00; I2 = 65.76%), and there was no demonstrated effect on severe preeclampsia. One trial also reported more low-birthweight infants with vitamin C and E (387…

Study & population

Systematic review and meta-analysis of 20 randomized controlled trials in women aged 18 to 50 who were at high risk for preeclampsia and were either planning pregnancy or already pregnant.

Intervention

This systematic review evaluated preconception and pregnancy micronutrient supplementation regimens aimed at preventing preeclampsia in high-risk women.

Key limitation

The evidence base was limited by small sample sizes, heterogeneity across trials, and variable methods, doses, timing of initiation, and co-formulations.

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Original abstract