Research paper
Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes
Citations: 47
Influential: 2
Systematic Reviews / Meta-Analyses
85
Study answer
What this study found
Overall, n-3 PUFA supplementation produced a small reduction in diastolic blood pressure and an increase in factor VII, but did not show significant effects on systolic blood pressure, fibrinogen in the main comparison, or heart rate. In pooled analyses, diastolic blood pressure fell by -1.79 mmHg (95% CI -3.56 to -0.02, p=0.05), factor VII increased by 24.9% (95% CI 7.2 to 42.6, p=0.006), systolic blood pressure changed by -1.69 mmHg (95% CI -5.04 to 1.65, p=0.32), and heart rate by -2.0 beats/min (95% CI -8.1 to 4.1, p=0.52). Fibrinogen was not significantly changed versus fibre control…
- Study & population
- Systematic review and meta-analysis of 12 randomized controlled trials in adults with type 2 diabetes.
- Intervention
- Marine-derived n-3 polyunsaturated fatty acid supplementation, mainly EPA and DHA, was tested in adults with type 2 diabetes.
- Key limitation
- The evidence base was limited by small trial sizes, short intervention duration, and heterogeneity in doses, formulations, and comparators.
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