Research paper
Maternal vitamin D status determines bone variables in the newborn.
Study answer
What this study found
Newborns of mothers with above-median vitamin D status had higher tibial bone mineral content (BMC) and cross-sectional area (CSA) at the 20% site (BMC 0.047 g/cm, 95% CI 0.011–0.082; CSA 12.3 mm2, 95% CI 2.0–22.6), with P values <0.01 and <0.02 respectively. Areal bone mineral density (BMD) showed no difference between groups. After adjusting for birthweight Z-score and maternal height (and newborn age), BMC and CSA differences remained significant, while BMD remained non-significant. Cord S-25-OHD correlated positively with BMC and CSA; maternal postpartum PTH inversely correlated with…
- Study & population
- 125 healthy, nonsmoking, primiparous Caucasian pregnant women aged 20–40 with singleton, uncomplicated full-term pregnancies were recruited at a birth hospital in Helsinki, Finland.
View source
Open PDFOriginal abstract
CONTEXT Vitamin D regulates 3% of the human genome, including effects on bone health throughout life. Maternal vitamin D status may program neonatal skeletal development. The objective here was to determine the association of mothers' vitamin D statu…