Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

Study answer

What this study found

Magnesium supplementation altered vitamin D metabolism in a baseline-dependent way rather than producing one uniform effect. At baseline 25(OH)D of 30 ng/mL, magnesium increased 25(OH)D3 versus placebo by 2.79 ng/mL, but at 50 ng/mL it lowered 25(OH)D3 by 6.87 ng/mL and lowered 24,25(OH)2D3 by 1.85 ng/mL. Magnesium also increased 25(OH)D2 as baseline 25(OH)D rose, with the largest difference at 50 ng/mL: 8.39 ng/mL. The authors concluded that optimal magnesium status may be important for optimizing 25(OH)D status and that further dosing studies are needed to clarify clinical relevance.

Study & population

This was a double-blind randomized ancillary trial within a colorectal cancer prevention study at Vanderbilt University Medical Center in Nashville, Tennessee, USA.

Intervention

Personalized oral magnesium capsules were given daily for 12 weeks in a double-blind design.

Key limitation

The trial was relatively small, short in duration, and conducted at a single U.S.

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Original abstract