Research paper
Is Matrix Gla Protein Associated with Vascular Calcification? A Systematic Review
Study answer
What this study found
Overall, vitamin K supplementation reduced dp-ucMGP but did not reliably slow vascular calcification progression. In the included intervention studies, dp-ucMGP rose with increasing aortic calcification severity in hemodialysis patients, but the baseline calcification score did not correlate with the subsequent dp-ucMGP drop. In CKD stages 3-5, there was no difference in coronary CAC progression between MK-7 plus cholecalciferol and comparator treatment, and CAC still increased despite MK-4 treatment; in postmenopausal women, neither baseline nor change in MGP concentrations predicted CAC…
- Study & population
- Systematic review of observational studies and randomized trials examining circulating matrix Gla protein fractions and vascular calcification.
- Intervention
- Included interventional studies evaluated vitamin K regimens across several populations: MK-7 360 µg once daily in hemodialysis patients; MK-7 90 µg plus cholecalciferol 10 µg in non-dialyzed CKD stages 3-5; MK-4 15 mg three times daily plus cholecalciferol 10 µg in cardiovascular disease; and phylloquinone 500 µg…
- Key limitation
- The evidence was highly heterogeneous in calcification territory, MGP fraction measured, populations, and study design.
View source
Open PDFOriginal abstract
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla protein (MGP), a tissue-derived vitamin K dependent protein, is reported to be an important inhibitor of vascular calcification and may have clinical pote…