Research paper

Iron Supplementation in Iron-Replete and Nonanemic Pregnant Women in Tanzania: A Randomized Clinical Trial.

JAMA pediatrics

Oct 2015

DOI: 10.1001/jamapediatrics.2015.1480

Citations: 58

Influential: 2

Interventional (Human) Studies

Study answer

What this study found

Iron supplementation did not increase placental malaria or other major adverse outcomes, and it improved maternal iron status at delivery. Placental malaria was similar with iron vs placebo for any placental malaria (33 [6.7] vs 33 [6.5]; RR 1.03, 0.65-1.65; P=.89), microscopic placental malaria (11 [2.3] vs 10 [2.1]; RR 1.14, 0.49-2.65; P=.77), and submicroscopic placental malaria (26 [5.3] vs 24 [4.8]; RR 1.12, 0.65-1.92; P=.69). Maternal hemoglobin at delivery was higher with iron (11.8 [2.0] g/dL vs 10.9 [1.9] g/dL; P<.001), ferritin was higher (92.5 [171.1] μg/L vs 54.1 [90.3] μg/L;…

Study & population: Randomized clinical trial in Dar es Salaam, Tanzania, enrolling HIV-negative primigravidae or secundigravidae at or before 27 weeks' gestation who were nonanemic and iron-replete at screening.
Intervention: Daily oral iron supplementation with 60 mg elemental iron as ferrous sulfate from enrollment until delivery, compared with placebo.
Key limitation: The placental analysis subset was smaller than the full randomized cohort, with placental samples available for 493 participants and birth outcomes for 731, which limits precision for rarer outcomes.

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Original abstract

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