Intravenous iron increases labile serum iron but does not impair forearm blood flow reactivity in dialysis patients.

Study answer

What this study found

A single 300 mg intravenous iron sucrose infusion increased circulating labile iron markers and raised basal forearm blood flow, but it did not impair vascular reactivity. After iron, total iron, non-transferrin-bound iron, and redox-active iron increased, and basal forearm blood flow was 3.73 mL/min/100 mL versus 2.34 mL/min/100 mL after placebo (P < 0.05 vs baseline, P < 0.01 vs iron). However, responses to acetylcholine, GTN, and L-NMMA remained similar before and after iron, with no significant between-group difference in forearm blood flow reactivity (P = 0.08). The authors interpreted…

Study & population

Randomized placebo-controlled study in stable adults with end-stage renal disease on peritoneal dialysis (CAPD or APD) at the Medical University Vienna.

Intervention

A single 300 mg intravenous iron sucrose infusion (Venofer) was given over 2 hours in 50 mL 0.9% sodium chloride.

Key limitation

Small single-arm sample and short-term, single-dose exposure limit inference about longer-term cardiovascular safety.

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Original abstract