Research paper
Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies
Study answer
What this study found
Saturated fat intake showed no significant associations with all-cause mortality (RR 0.99; 95% CI 0.91–1.09), CVD mortality (0.97; 0.84–1.12), total CHD (1.06; 0.95–1.17), ischemic stroke (1.02; 0.90–1.15), or type 2 diabetes (0.95; 0.88–1.03); CHD mortality lack of association not convincing (1.15; 0.97–1.36; P=0.10). Total trans fats were associated with higher risk of all-cause mortality (RR 1.34; 1.16–1.56), CHD mortality (1.28; 1.09–1.50), and total CHD (1.21; 1.10–1.33); ischemic stroke (1.07; 0.88–1.28) and type 2 diabetes (1.10; 0.95–1.27) not clearly linked. Industrial trans fats…
- Study & population
- Design: Systematic review and meta-analysis of observational data; Participants: adults from general populations across the US, UK, Japan, Sweden, Israel, Finland, Denmark, Canada, China, Greece, and Australia; baseline health: generally healthy; Study designs: primarily prospective cohort studies used for quantitative synthesis, with supplementary…
- Key limitation
- Observational design limits causal inference; very low certainty for saturated fat associations due to imprecision and inconsistency; heterogeneity and imprecision across studies; measurement error and misclassification of fat exposures (dietary self-report and biomarkers); residual confounding and potential…
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Open PDFOriginal abstract
Objective To systematically review associations between intake of saturated fat and trans unsaturated fat and all cause mortality, cardiovascular disease (CVD) and associated mortality, coronary heart disease (CHD) and associated mortality, ischemic …