Research paper
Impact of Vitamin D Supplementation during Lactation on Vitamin D Status and Body Composition of Mother-Infant Pairs: A MAVID Randomized Controlled Trial
Study answer
What this study found
Higher-dose maternal vitamin D3 improved maternal vitamin D status more than 400 IU/d, but neither dose fully corrected deficiency and there was no benefit for infant vitamin D status, bone mass, or body composition. Maternal 25(OH)D at 6 months was 25.6 ng/mL with 400 IU/d versus 23.1 ng/mL with 1200 IU/d, P = 0.009, while maternal 25(OH)D <20 ng/mL at 6 months was 29.9% versus 14.3%, P = 0.028. Infants' 25(OH)D increased with their own supplementation, but between-group differences were not significant (group x time interaction P = 0.12; group effect P = 0.45). Maternal and infant iPTH,…
- Study & population
- Randomized controlled trial in healthy, term, Caucasian lactating mother-infant pairs recruited in Warsaw, Poland.
- Intervention
- Lactating mothers received oral vitamin D3 (cholecalciferol) for 6 months starting about 3 weeks postpartum.
- Key limitation
- The trial had modest effective sample size after attrition, with 174 randomized and 137 analyzed for the primary outcome.
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Open PDFOriginal abstract
Objective The optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant’s …