Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study.

What this study found

High-phenolic olive oil did not outperform low-phenolic olive oil. Both oils were associated with within-group decreases in the urinary CAD proteomic score of 0.3 and 0.2 units, respectively, at endpoint (P < 0.01), but there was no difference between groups for CAD improvement. There were no significant effects on CKD or diabetes biomarkers, and plasma lipid measures also did not differ significantly between groups. No harms or unintended effects were recorded.

Study & population

Randomized, parallel-group, controlled, double-blind study in healthy adults aged 18 to 75 years who were non-regular olive oil consumers and had no diagnosed illness.

Intervention

Participants received 20 mL/day of olive oil by mouth for 6 weeks.

Key limitation

The trial was short (6 weeks) and small, with only 34 and 29 completers in the active arms.

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