Research paper
Hyperemesis gravidarum and vitamin K deficiency: a systematic review
Study answer
What this study found
Vitamin K deficiency and related complications were reported in hyperemesis gravidarum, and supplementation was associated with normalization of prothrombin time in the reported cases. Among 21 women in the case reports, 8/21 (38.1%) had prolonged prothrombin time; in the cohort study, 10/39 (25.6%) had prolonged prothrombin time, and 2/10 had levels below 50%. Vitamin K was administered to 10/21 women and 1 neonate, with most maternal cases receiving intravenous vitamin K. Reported complications included maternal coagulopathy-related hemorrhage and neonatal intracranial haemorrhage or…
- Study & population
- Systematic review of case reports and one retrospective cohort study in pregnant women with hyperemesis gravidarum and vitamin K-related coagulopathy or deficiency, with some neonatal outcomes also described.
- Intervention
- Vitamin K supplementation was used to treat or prevent vitamin K deficiency in pregnancies complicated by hyperemesis gravidarum.
- Key limitation
- The evidence is limited to case reports plus one retrospective cohort, so incidence and causality cannot be established.
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Open PDFOriginal abstract
Abstract Hyperemesis gravidarum (HG), severe nausea and vomiting in pregnancy, can lead to vitamin deficiencies. Little is known about HG-related vitamin K deficiency. We aimed to summarise available evidence on the occurrence of HG-related vitamin K…