High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high–oleic acid meal: a randomized controlled trial

Study answer

What this study found

Overall, EPA plus DHA fish oil and DHA-only algal oil produced different acute postprandial oxidative stress responses, but neither meal consistently improved postprandial lipemia or vascular function. Compared with the high-oleic acid control meal, TAG decreased after fish oil at 4, 5, and 6 h (P < 0.05), while algal oil reduced the magnitude of NEFA suppression during 0-3 h and showed higher NEFA at 1, 2, and 3 h vs control. The key divergence was 8-isoprostane F2alpha: fish oil increased it at 6 h vs control, whereas algal oil reduced it vs both control and fish oil. No differences were…

Study & population

Randomized, double-blind, crossover, single-center trial at King's College London in the United Kingdom.

Intervention

Participants consumed single oral high-fat test meals enriched with either 5 g EPA plus DHA from fish oil (Incromega TG4030-(LK)) or 5 g DHA from marine microalgal oil (DHASCO).

Key limitation

The active arms were small (16 participants each), which limits precision and power for secondary endpoints.

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Original abstract