Research paper
Hesperidin Bioavailability Is Increased by the Presence of 2S-Diastereoisomer and Micronization—A Randomized, Crossover and Double-Blind Clinical Trial
Citations: 14
Influential: 1
Interventional (Human) Studies
81
Study answer
What this study found
The bioavailability of micronized 2S-hesperidin was significantly higher than that of the standard mixture and the micronized epimeric mixture, largely due to greater formation of hesperidin catabolites. Micronization resulted in improved absorption.
- Study & population
- Thirty healthy participants were recruited, with 15 ultimately participating in the randomized, crossover, double-blind intervention.
- Intervention
- The effects of three different types of hesperidin supplements were evaluated: a conventional epimeric mixture (HEM), a micronized epimeric mixture (MHEM), and a micronized 2S-hesperidin (M2SH).
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Open PDFOriginal abstract
Hesperidin is a flavanone abundantly found in citrus fruits for which health beneficial effects have been reported. However, hesperidin shows a low bioavailability among individuals. The aim of this study was to evaluate the effects of the micronizat…