Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: A combined analysis

Study answer

What this study found

Higher-dose vitamin D3 improved maternal and neonatal vitamin D status, but did not show clear statistically significant reductions in pregnancy comorbidities. Final maternal 25(OH)D was higher with 2000 IU/day and 4000 IU/day than control (37.1 and 41.9 ng/mL vs 30.7 ng/mL), and cord blood 25(OH)D was also higher with 4000 IU/day (25.4 ng/mL vs 18.2 ng/mL). Vitamin D sufficiency increased with dose, including maternal 25(OH)D >=32 ng/mL in 68.7% of the 2000 IU group and 76.2% of the 4000 IU group. The authors concluded that higher-dose supplementation was associated with better vitamin D…

Study & population

Combined analysis of two randomized pregnancy supplementation trials conducted in South Carolina.

Intervention

Vitamin D3 (cholecalciferol) was given orally as a daily regimen during pregnancy.

Key limitation

Clinical outcome findings were not definitive, with no significant between-group differences for the comorbidity composites despite biomarker improvements.

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Original abstract