Research paper

Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study

British Journal of Nutrition

Jan 2018

DOI: 10.1017/S0007114517003440

Citations: 196

Influential: 10

Interventional (Human) Studies

Study answer

What this study found

Overall, the prebiotic produced a stronger gut microbiota response in participants with high habitual fibre intake than in those with low intake. In the whole cohort, Bifidobacterium increased significantly (P < 0.001), while Coprococcus (P = 0.016), Dorea (P = 0.029), Ruminococcus (Lachnospiraceae) (P = 0.007), and Oscillospira (P = 0.031) decreased; Faecalibacterium showed a nonsignificant upward trend (P = 0.088). In the high-fibre group, Bifidobacterium increased (P < 0.001) and Faecalibacterium increased (P = 0.010), with decreases in Coprococcus (P = 0.010), Dorea (P = 0.043), and…

Study & population: Randomized, double-blind, placebo-controlled, cross-over human intervention study in healthy adults from New Zealand.
Intervention: Participants received 16 g/day of an inulin-type fructan prebiotic (Orafti Synergy1, a 50:50 inulin-to-fructooligosaccharide mix) for 3 weeks, given as two 8 g doses per day.
Key limitation: The analysis was small and short term, with only 34 participants evaluated over 3-week intervention periods.

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Original abstract

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