Gynostemma pentaphyllum for dyslipidemia: A systematic review of randomized controlled trials

Study answer

What this study found

Very low certainty evidence suggests Gynostemma pentaphyllum can improve lipid outcomes, but the size and reliability of the effect are uncertain. As a stand-alone treatment, it appeared comparable to lipid-lowering agents for total cholesterol, triglycerides, and HDL-C, but inferior to red yeast rice for total cholesterol, triglycerides, and HDL-C. As an add-on to lipid-lowering therapy, it may produce greater improvements in triglycerides, LDL-C, and HDL-C than lipid-lowering therapy alone. Safety data favored Gynostemma pentaphyllum, with fewer adverse events than lipid-lowering drugs and…

Study & population

Systematic review of 22 randomized controlled trials including 2,407 adults with dyslipidemia.

Intervention

Gynostemma pentaphyllum was tested in multiple forms across trials, including gypenosides tablets or capsules, Gynostemma tea, and one adjunctive regimen combined with fenofibrate.

Key limitation

The certainty of evidence was very low to low, limiting confidence in the findings.

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Original abstract