Research paper
Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
Study answer
What this study found
Hypertension is associated with gut microbiota dysbiosis, including decreased alpha diversity and altered microbial composition. Depletion of short-chain fatty acid-producing bacteria (Faecalibacterium, Roseburia, Ruminococcus, Bifidobacterium, Akkermansia) and overgrowth of certain Proteobacteria and Bacteroidetes are reported. Functional analyses show up-regulation of lipopolysaccharide biosynthesis, phosphotransferase system, and ABC transporters, with down-regulation of some amino acid metabolism. Fecal short-chain fatty acids (SCFAs) levels are increased, while plasma SCFAs are…
- Study & population
- Adults with hypertension and normotensive controls; 17 observational studies (n=9,085) across multiple countries; stool samples analyzed for gut microbiota via 16S rRNA gene sequencing and/or metagenomic sequencing; quality assessed with Newcastle-Ottawa Scale (NOS); PRISMA-based systematic review; PROSPERO registration CRD42020212219.
- Key limitation
- Limitations: Potential selection bias and lack of representativeness; variable hypertension definitions across studies; geographic concentration in China and the US; language restrictions (English/Chinese abstracts); many studies cross-sectional, limiting causal inferences; methodological heterogeneity (16S vs…
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Open PDFOriginal abstract
Introduction: Hypertension is one of the major risk factors to human health and human studies on association between gut microbiota and hypertension or blood pressure have received increased attention. In the present study, we aim to evaluate gut mic…